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Andrade,S.A.; Carrijo-Carvalho,L.C.; Peceguini,L.A.M.; Wlian,L.; Sato,A.C.; Luchiari,C.; Silva,E.D.; Maffei,F.H.A.; Chudzinski-Tavassi,A.M.. |
Lopap, found in the bristles of Lonomia obliqua caterpillar, is the first exogenous prothrombin activator that shows serine protease-like activity, independent of prothrombinase components and unique lipocalin reported to interfere with hemostasis mechanisms. To assess the action of an exogenous prothrombin activator reversing the anticoagulant and antihemostatic effect induced by low molecular weight heparin (LMWH), male New Zealand rabbits (N = 20, weighing 3.8-4.0 kg) allocated to 4 groups were anticoagulated with 1800 IU/kg LMWH (iv) over 2 min, followed by iv administration of saline (SG) or recombinant Lopap (rLopap) at 1 µg/kg (LG1) or 10 µg/kg (LG10), 10 min after the injection of LMWH, in a blind manner. Control animals (CG) were treated only with... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Prothrombin activation; Procoagulant; Exogenous hemostatic factor; RLopap; Bleeding; Anticoagulant. |
Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001000007 |
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